Jerath, Gaurav and Santhoshkumar, T.R. (2019) Syndiotactic peptides for targeted delivery. Acta Biomaterialia, 87. pp. 130-139. ISSN 1742-7061

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Abstract

Lack of cell-type specificity and proteolytic susceptibility have long been the major bottlenecks for the development of peptide-based biomaterials for targeted drug delivery. Though a poly-l backbone provides the adaptability to re-conform the peptide structure to bind to a receptor, it also makes the peptide more susceptible to proteolytic cleavage. We have attempted to address this issue by designing a set of syndiotactic peptides de novo, with alternating l- and d-amino acids in succession. The designed peptides have higher rates of cellular uptake than the Tat (48–60) peptide in breast and cervical cancer cells. The uptake is independent of concentration, temperature and endocytosis (clathrin mediated). Importantly, the peptides are stable in both human plasma and bovine serum. The peptide-drug conjugates are much less toxic to the non-cancerous cells than cancer cells. The designed peptides are a step forward towards the development of targeted drug delivery vectors on peptide templates.

Item Type:	Article
Uncontrolled Keywords:	Cancer therapy Cell penetrating peptides Drug delivery vehicles Protein design Tumor homing
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	25 Jul 2019 09:32
Last Modified:	25 Jul 2019 09:33
URI:	http://rgcb.sciencecentral.in/id/eprint/827

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