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Sreejith, P.S. and Asha , V.V. (2015) Glycopentalone, a novel compound from Glycosmis pentaphylla (Retz.) Correa with potent anti-hepatocellular carcinoma activity. Journal of ethnopharmacology., 172. ISSN 1872-7573

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Ethnopharmacological relevance Glycosmis pentaphylla (Retz.) Correa is used in Indian traditional medicine against various liver ailments, including cancer. Aim of the study Isolation and characterization of the most active anti-hepatocellular carcinoma (HCC) compound from the alcohol extract of G. pentaphylla. Materials and methods Different chromatographic (HPLC, TLC and column chromatography) and methods like IR, LCMS and NMR were used for the isolation and structural identification of the active anti-HCC compound from G. pentaphylla. Cytotoxic and apoptosis inducing effect of the active compound were assessed in Hep3 B, RAW264.7 and HEK293 cell lines by MTT assay, morphological studies, Hoechst staining and Annexin V FITC assay.

Item Type: Article
Uncontrolled Keywords: Anticancer; Apoptosis; Chalcone; Glycopentalone; Glycosmis pentaphylla
Subjects: Disease Biology
Depositing User: Rgcb Library
Date Deposited: 28 Dec 2016 09:47
Last Modified: 22 Apr 2019 08:36
URI: http://rgcb.sciencecentral.in/id/eprint/83

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