Partha , Basu and Devasena , Anantharaman and Priya R. , Prabhu and Subha , Sankaran and Thiraviam Pillai Rameshwari , Ammal Kannan and Rintu , Varghese (2019) Two-dose recommendation for Human Papillomavirus vaccine can be extended up to 18 years – updated evidence from Indian follow-up cohort study. Papillomavirus research. pp. 75-81. ISSN 2405-8521

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Abstract

Earlier publication from the ongoing multi-centric study of the International Agency for Research on Cancer to evaluate less than three doses of the quadrivalent Human Papillomavirus (HPV) vaccine in India amongst unmarried girls demonstrated non-inferior total antibody titres, neutralizing antibody titres and antibody avidity in 2-dose recipients compared to 3-dose recipients at 15–18 years of age (Bhatla et al., 2018) [7]. The number of participants recruited at 15–18 years of age was 1515 and 1795 in the 3-dose and the 2-dose groups respectively. At a median follow-up of 7 years, incident HPV 16/18 infections were detected in 1.6% women receiving two doses and 0.8% women receiving three doses at 15–18 years. Frequency of incident infection was 7.0% in the age- and site-matched unvaccinated women (N = 1484). No persistent infection from HPV 16 was observed in the 2- or 3-dose recipients and one (0.2%) persistent HPV 18 infection was documented, each in the 3-dose and 2-dose cohorts. Among the unvaccinated women, the frequency of HPV 16/18 persistent infection was 1.7%. The protection offered by two doses of quadrivalent HPV vaccine against incident and persistent infections in recipients at 15–18 years is comparable to that seen in 3-dose recipients at 15–18 years.

Item Type:	Article
Uncontrolled Keywords:	Human papillomavirus, Quadrivalent vaccine, Two doses, Age 15–18 years, Immunogenicity, Incident infections, Persistent infections
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	23 Aug 2019 07:19
Last Modified:	23 Aug 2019 07:20
URI:	http://rgcb.sciencecentral.in/id/eprint/848

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