Patel, Mohanakumara and T R, Santhoshkumar (2010) Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine. Fitoterapia, 81 (2). pp. 145-148. ISSN 1873-6971

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Abstract

Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.

Item Type:	Article
Uncontrolled Keywords:	Dysoxylum binectariferum Rohitukine Anticancer activity Flavopiridol
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	19 Sep 2019 06:38
Last Modified:	19 Sep 2019 06:38
URI:	http://rgcb.sciencecentral.in/id/eprint/870

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