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Bibbin T, Paul and Mani S., Babu and T.R. , Santhoshkumar and Devarajan, Karunagaran (2009) Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agents. Journal of photochemistry and photobiology. B, Biology, 94 (1). pp. 38-44. ISSN 1873-2682

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Two novel cyclohexane-1,2-diamino and N,N dimethyl amino-propyl substituted hypocrellin B derivatives, abbreviated as CHA2HB and DMAHB, respectively were synthesized. These derivatives exhibited enhanced absorption in phototherapeutic window. Photodynamic action of these derivatives, investigated using optical and electron spin resonance methods, depended on both Type I and Type II mechanisms. Gel electrophoresis indicated 1O2/O2(.-) mediated DNA damage. CHA2HB displayed 20 fold increase in light dependent cytotoxicity on colon cancer cell line (HCT 116) than the well-known hypocrellin B (HB). The light induced, LD(50) values for CHA2HB and DMAHB were found to be 0.1 microM and 1.5 microM, respectively. The singlet oxygen generating efficiency followed the order HB>CHA(2)HB>DMAHB. But, the enhanced red absorption as well as the hydrophilicity renders the CHA2HB a better photodynamic therapeutic agent.

Item Type: Article
Uncontrolled Keywords: Hypocrellin Photodynamic therapy Human colon cancer cell Cytotoxicity DNA damage Photosensitization
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 04 Oct 2019 05:32
Last Modified: 04 Oct 2019 05:32
URI: http://rgcb.sciencecentral.in/id/eprint/885

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