Suboj , Babykutty and Thasni Karedath , Abdul Azis and Priya, Srinivas (2009) APOPTOSIS INDUCTION OF CENTELLA ASIATICA ON HUMAN BREAST CANCER CELLS. AJTCAM, 6 (1). pp. 9-16. ISSN 0189-6016

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Abstract

The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable.

Item Type:	Article
Uncontrolled Keywords:	Apoptosis, Cancer, Centella asiatica
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	08 Nov 2019 06:58
Last Modified:	08 Nov 2019 06:58
URI:	http://rgcb.sciencecentral.in/id/eprint/900

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