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SAVNEET, KAUR and KARTHA, C C (2009) Stem cells: Concepts and prospects. Current trends in science Platinum jubilee special . ISSN ISBN:9788185324166.

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Regenerative therapy for organ dysfunction is a rapidly growing domain and involves application of multiple enabling technologies incorporating stem cells, genes and growth factors that can accelerate the recovery of a failing organ through cell and tissue regeneration within the organ. Several strategies are currently being evaluated for regeneration of damaged organs. These are aimed at ‘reviving’ existing malfunctioning cells, repopulating the organ by new cells from exogenous or endogenous sources, altering the extracellular matrix, or increasing blood supply by enhancing vasculogenesis. Stem cells with their unique and facile potentialities, offer building blocks for organ development and tissue repair. Over the years, a number of preclinical and small clinical trials have shown that tissue regeneration can be induced when stem cells of various types – embryonic stem cells, stem cells from cord blood and bone marrow, and adult stem cells – are injected into injured or degenerated tissue. Several small clinical trials have reported varying degrees of functional improvement. There are also attempts to use the progenitor cells to deliver functional genes as well as to seed the progenitor cells onto implants to improve the biocompatibility of implants. The promising results from many centers involved in the treatment of endstage diseases using stem cells highlight the wide range of possibilities in this field. Despite its very early stage, almost every major medical center across the globe is involved in at least one cell therapy effort. Companies are viewing at multibillion dollar markets in cell therapy in the future. This review summarizes the current concepts in stem cell biology and important advancements and limitations with respect to their prospective use in regeneration therapies in various human diseases.

Item Type: Article
Uncontrolled Keywords: Stem cells; progenitor cells; cell transplantation; diseases; repair; regenerative therapy. 437
Subjects: Cardiovascular Diseases And Diabetes Biology
Depositing User: Rgcb Library
Date Deposited: 13 Nov 2019 06:49
Last Modified: 13 Nov 2019 06:49
URI: http://rgcb.sciencecentral.in/id/eprint/903

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