Brahmaraju, M. and Malini , Laloraya and Pradeep G. , Kumar (2009) Immunodominant sperm antigens and their role in male infertility. Current Paradigm of Reproductive Immunology. pp. 59-81. ISSN ISBN: 978-81-308-0373-9

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Abstract

Abstract. Antibodies to sperm proteins are known to be present in the male and female circulation, and their presence is often found to be associated with human infertility. Sperm proteins located on the head, mid-piece and tail have been shown to be auto- or isoantigenic, and their effect would vary depending on the function of the antigen involved. In addition to their use as molecules for clinically explaining human infertility, generation of autoantibodies has been tried as an experimental way to suppress fertility in otherwise fertile subjects, thus evolving this strategy as an immunocontraceptive procedure. This review is an attempt to collect all known antigens of spermatozoa of seminal fluid origin that had demonstrated negative effect on fertility.

Item Type:	Article
Subjects:	Molecular Reproduction
Depositing User:	Central Library RGCB
Date Deposited:	14 Nov 2019 11:52
Last Modified:	14 Nov 2019 11:52
URI:	http://rgcb.sciencecentral.in/id/eprint/906

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