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Nomesh , Yadu and Pradeep , G. Kumar (2019) Retinoic acid signaling in regulation of meiosis during embryonic development in mice. genesis. ISSN 1526-968X

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Abstract

In the embryonic gonads of mice, the genetic and epigenetic regulatory programs for germ cell sex specification and meiosis induction or suppression are intertwined. The quest for garnering comprehensive understanding of these programs has led to the emergence of retinoic acid (RA) as an important extrinsic factor, which regulates initiation of meiosis in female fetal germ cells that have attained a permissive epigenetic ground state. In contrast, germ cells in fetal testis are protected from the exposure to RA due to the activity of CYP26B1, an RA metabolizing enzyme, which is highly expressed in fetal testis. In this review, we provide an overview of the molecular mechanisms operating in fetal gonads of mice, which enable regulation of meiosis via RA signaling.

Item Type: Article
Uncontrolled Keywords: embryonic germ cells, germ cell fate determination, meiosis, retinoic acid signaling, Stra8
Subjects: Molecular Reproduction
Depositing User: Rgcb Library
Date Deposited: 28 Jan 2020 06:56
Last Modified: 28 Jan 2020 06:56
URI: http://rgcb.sciencecentral.in/id/eprint/940

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