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Krithika, S. and Sumi, S. (2020) Neurovascular inflammation in the pathogenesis of brainarteriovenous malformations. J of Cellular Physiology. pp. 1-16. ISSN 1097-4652

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Abstract

Brain arteriovenous malformations (bAVM) arise as congenital or sporadic focallesions with a significant risk for intracerebral hemorrhage (ICH). A wide range ofinterindividual differences is present in the onset, progression, and severity ofbAVM. A growing body of gene expression and polymorphism‐based researchstudies support the involvement of localized inflammation in bAVM diseaseprogression and rupture. In this review article, we analyze the altered responses ofneural, vascular, and immune cell types that contribute to the inflammatory process,which exacerbates the pathophysiological progression of vascular dysmorphogen-esis in bAVM lesions. The cumulative effect of inflammation in bAVM developmentis orchestrated by various genetic moderators and inflammatory mediators. We alsodiscuss the potential therapies for the treatment of brain AVM by targeting theinflammatory processes and mediators. Elucidating the precise role of inflammationin the bAVM growth and hemorrhage would open novel avenues for noninvasiveand effectual causal therapy that may complement the current therapeuticstrategies

Item Type: Article
Uncontrolled Keywords: arteriovenous malformations, brain AVM, hereditary hemorrhagic telangiectasia, intracerebralhemorrhage, neuroinflammation
Subjects: Cardiovascular Diseases And Diabetes Biology
Depositing User: Rgcb Library
Date Deposited: 06 Jan 2021 07:12
Last Modified: 06 Jan 2021 07:12
URI: http://rgcb.sciencecentral.in/id/eprint/993

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