Pallara J , Wills and VV, Asha (2012) Acute and subacute toxicity studies of Lygodium flexuosum extracts in rats. Asian Pacific Journal of Tropical Biomedicine, 2 (1). S200-S202. ISSN 2221-1691

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Abstract

Objective To investigate the acute and subacute toxicity of Lygodium flexuosum (L. flexuosum) extracts to substantiate the tribal or folk claims for its use as a safe hepatoprotective drug. Methods The water, ethanol and n-hexane extracts of L. flexuosum were tested in vivo in Wistar rats. In acute toxicity model, rats received a single dose (5 g/kg) of water extract, ethanol extract, and n-hexane extract of L. flexuosum and kept under observation for 14 d. In subacute toxicity studies, animals were treated with daily doses (1 g/kg body weight) of water, ethanol and n-hexane extract respectively for 30 d. Results In acute toxicity, the extracts administration up to a higher dose of 5 g/kg did not result in mortality or any change in behavior and biochemical parameters of the animals. Sub acute toxicity studies in rats showed that treatment with the extracts did not alter the serum biochemical and hematological parameters. Conclusions The extracts were found to be devoid of any toxicity in acute (5 g/kg) and subacute (1 g/kg) toxicity evaluation in rats.

Item Type:	Article
Uncontrolled Keywords:	Lygodium flexuosum; Lygodiaceae; Acute toxicity; Subacute toxicity
Subjects:	Plant Disease Biology & Biotechnology
Depositing User:	Central Library RGCB
Date Deposited:	13 Feb 2017 04:53
Last Modified:	13 Feb 2017 04:53
URI:	http://rgcb.sciencecentral.in/id/eprint/227

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