Dhanya, R and Kartha, C. C. (2021) Quercetin improves oxidative stress‑induced pancreatic beta cell alterations via mTOR‑signaling. Molecular and cellular biochemistry, 476 (11). ISSN 1573-4919

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Abstract

Citrus flavonoids particularly quercetin which is abundant in grapefruit, onion, green tea, berries etc. are known to have a protective effect on oxidative stress. Pancreatic β cells which synthesize and secrete insulin are prone to oxidative stress induced damage because of low cellular antioxidant enzymes. To delineate the effects of quercetin on pancreatic β cells we evaluated the protective effect of quercetin on TC6 insulinoma cells subjected to oxidative stress induced by tert-butyl- hydrogen-peroxide (TBHP). Quercetin was found to reduce TBHP induced apoptosis and trigger insulin secretion in response to glucose, in a dose-dependent manner. Quercetin treatment increased mitochondrial biogenesis, caused hypertrophy in pancreatic β cells and activated mTOR signaling with a transient change in mitochondrial membrane potential and AMP/ ATP. Activation of mTOR signaling resulted in enhanced insulin secretion in TC6 cells.

Item Type:	Article
Uncontrolled Keywords:	Bioactive compound; Quercetin; TBHP; Type 2 diabetes; mTOR.
Subjects:	Cardiovascular Diseases And Diabetes Biology
Depositing User:	Central Library RGCB
Date Deposited:	18 Jan 2022 06:03
Last Modified:	18 Jan 2022 06:04
URI:	http://rgcb.sciencecentral.in/id/eprint/1099

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