Jonathan, Pommer Hansen and Rajeeve , Sivadasan and Karthika, Rajeeve (2021) Bacteria-Cancer Interface: Awaiting the Perfect Storm. Pathogens (Basel, Switzerland), 10 (10). ISSN 2076-0817

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Abstract

Epidemiological evidence reveal a very close association of malignancies with chronic inflammation as a result of persistent bacterial infection. Recently, more studies have provided experimental evidence for an etiological role of bacterial factors disposing infected tissue towards carcinoma. When healthy cells accumulate genomic insults resulting in DNA damage, they may sustain proliferative signalling, resist apoptotic signals, evade growth suppressors, enable replicative immortality, and induce angiogenesis, thus boosting active invasion and metastasis. Moreover, these cells must be able to deregulate cellular energetics and have the ability to evade immune destruction. How bacterial infection leads to mutations and enriches a tumour-promoting inflammatory response or micro-environment is still not clear. In this review we showcase well-studied bacteria and their virulence factors that are tightly associated with carcinoma and the various mechanisms and pathways that could have carcinogenic properties.

Item Type:	Article
Uncontrolled Keywords:	DNA damage; bacteria; cancer hallmarks; epithelial mesenchymal transition; inflammation.
Subjects:	Molecular Neurobiology Pathogen Biology
Depositing User:	Central Library RGCB
Date Deposited:	15 Mar 2022 10:05
Last Modified:	15 Mar 2022 10:05
URI:	http://rgcb.sciencecentral.in/id/eprint/1152

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