Sreelekha, M and Ruby John , Anto (2014) Cytotoxicity of 6-acetonyldihydro- chelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines. iNDIAN JOURNAL OF CHEMISTRY, 53. pp. 647-651. ISSN 0975-0983

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Abstract

The alkaloids, 6-acetonyldihydrochelerythrin 1 and arnottianamide 2 have been isolated for the first time from conical prickles on the stem bark of Zanthoxylum rhetsa (Roxb.) DC. These compounds have been investigated for their cytotoxicity against seven cancer cell lines of various origins. The compound 1 is proved to be more potent as an anticancer agent and is very specific to the colon cancer cell line, SW-480 and cervical cancer cell line, HeLa. Compound 2 is more active against breast cancer cell lines. The change in anticancer activity of 1 after conversion to 6-(2-hydoxypropyl)-dihydrochelerythrine 3 has also been evaluated and a decrease in activity is observed.

Item Type:	Article
Uncontrolled Keywords:	6-Acetonyldihydrochelerythrin, arnottianamide, 6-(2- hydoxypropyl)-dihydro chelerythrin, Zanthoxylum rhetsa , anticancer
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	06 Jan 2017 06:13
Last Modified:	22 Apr 2019 09:30
URI:	http://rgcb.sciencecentral.in/id/eprint/120

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