Siyad, MA and GS, Vinod Kumar (2013) PEGylated dendrimer polystyrene support: synthesis, characterisation and evaluation of biologically active peptides. Amino acids, 44 (3). pp. 947-959. ISSN 1438-2199

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Abstract

Poly(N,N-bisethylamine) dendrimers with high content of poly(ethylene glycol) were synthesized on 3-(Acryloyloxy)-2-hydroxypropylmethacrylate-crosslinked polystyrene (PS-AHMA) resin and tested in various conditions of solid phase peptide synthesis. The dendritic templates were generated to the second generation on cross-linker active site of 3-(Acryloyloxy)-2-hydroxypropylmethacrylate (AHMA). First generation dendrimer was designed by series of four-stage reactions, such as Schiff base incorporation, acidolytic cleavage, diazotization and thionyl chloride treatment and same synthetic routes were followed for second generation also. Poly(ethylene glycol) (PEG1000) has been grafted to second-generation dendrimer and used to check various physico-chemical parameters in Fmoc/Boc peptide synthetic conditions. The utility of PEGylated dendrimer support was demonstrated by synthesizing biologically potent linear as well as disulfide-bonded peptide by Fmoc method.

Item Type:	Article
Uncontrolled Keywords:	DendrimerSolid phase synthesisPoly(ethylene glycol)
Subjects:	Chemical Biology
Depositing User:	Central Library RGCB
Date Deposited:	02 Mar 2017 07:18
Last Modified:	02 Mar 2017 07:18
URI:	http://rgcb.sciencecentral.in/id/eprint/280

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