Mathan, Sankaran and Swathi U. , Lekshmi and Suparna, Sengupta (2014) A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrrolizidine hybrids. Molecular diversity, 18 (2). pp. 269-283. ISSN 1573-501X

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Abstract

An expedient route toward the synthesis of 4-hydroxyquinolone grafted spiropyrrolidines or pyrrolizidines has been accomplished through 1,3-dipolar cycloaddition reaction of various azomethine ylides derived from isatin or acenaphthalene and sarcosine with 4-hydroxyquinolone derivatives as dipolarophile. The regio and stereo chemical outcome of the cycloaddition reaction is ascertained by X-ray crystallographic studies and spectroscopic techniques of the cycloadducts. Furthermore, cytotoxicity evaluation of selected compounds showed significant inhibition of cell proliferation against cervical as well as colon cancer cell lines.

Item Type:	Article
Uncontrolled Keywords:	Multicomponent reaction Azomethine ylide 1,3-Dipolar cycloaddition Non-covalent interaction Cytotoxicity MCRs
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	13 Mar 2018 08:44
Last Modified:	13 Mar 2018 08:44
URI:	http://rgcb.sciencecentral.in/id/eprint/521

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