GANGADHARAN , RAJENDRAN and RUBY , JOHN ANTO and VINO T., CHERIYAN (2010) Synthesis, thermal and antitumour studies of Th(IV) complexes with furan-2-carboxaldehyde4-phenyl-3-thiosemicarbazone. Journal of the Serbian Chemical Society, 75 (6). pp. 749-761. ISSN 0352-5139

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Abstract

Thorium(IV) complexes with the Schiff base furan-2-carboxaldehyde4- phenyl-3-thiosemicarbazone (L) were synthesised and characterized. The composition and structure of the metal complexes were proposed based on elemental analysis, molar conductivity measurements, FTIR and 1H-NMR spectroscopy. The Schiff base behaves as a neutral bidentate ligand coordinating through the azomethine N and the thioketo S atoms. From various studies, complexes were ascertained the general formula [ThL2X4] and [ThL2Y2], where X represents NO3 –, NCS–, CH3COO–, CH3CHOHCOO–, ClO4 – and Y SO4 2–and C2O4 2–. The thermal behaviour of the nitrato and oxalato complexes was studied and kinetic and thermodynamic parameters were calculated using the Coats-Redfern Equation. The ligand and a representative complex [ThL2(NO3)4] were screened in vitro for their antitumour activity against the human cervical cancer cell line (HeLa). Keywords: thorium(IV) complexes; furan-2-carboxaldehyde4-phenyl-3- thiosemicarbazone; antitumour activity; thermal analysis.

Item Type:	Article
Uncontrolled Keywords:	thorium(IV) complexes; furan-2-carboxaldehyde4-phenyl-3- thiosemicarbazone; antitumour activity; thermal analysis.
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	19 Jun 2019 10:47
Last Modified:	19 Jun 2019 10:47
URI:	http://rgcb.sciencecentral.in/id/eprint/789

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